This paper aims to establish the current knowledge of modern and traditional typhoid therapy among the populace from the developing world. It will seek to develop any existing gap on this essential knowledge as far as public health is concerned with typhoid prevalence among developing nations. Limited data was established on the knowledge of typhoid (both traditional and modern) in the developing world. The literature revealed a considerable knowledge gap in the existing therapy for typhoid in developing countries. It also established two ramifications of the knowledge gap, which include higher incidences of multidrug-resistant strains of Salmonella typhi and increased cases of drug toxicities. The review recommends a need for the establishment of elaborate intervention to address the existence of a knowledge gap of both modern and traditional therapies in developing countries, mostly in rural and informal settlements.